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***MS-1新型机能性益生菌株[蜜蜂益活菌]、诞生縁由***
（日本专利第4913117号）
1973年、诺贝尔生理学暨医学奖得主、Dr. Karl von Frisch、证明了蜜蜂高敏锐的环境感知能力与高效率沟通能力。现今因自然环境的异变与农药的影响、导致蜜蜂的锐减。蜜蜂与自然环境生态的关系是如此息息相关、密不可分。
近年世界各地蜜蜂突然大量死亡失踪的现象加剧,科学专家们认为会导致此令人忧心现象之因素包括营养不良、免疫力低下、电磁波、人类大量使用农药、抗生素、化学肥料、虫害、病毒感染等等••
2005年、日本养蜂协会(http://bee.lin.gr.jp/)特别专案请托在微生物防治法领域具研究成果与推广实绩的著名专家--前田昌调博士(宫崎大学农学部教授)以其长期专研之以优势机能菌株来取代抗生药剂抗病毒的最新自然环保技法（微生物防治法/Bio Control Method）以帮助解决蜜蜂因病毒感染及免疫力低下所造成的大量减少与死亡问题。
前田教授(Dr. Masachika Maeda之专门研究：微生物学)带领研究团队在宫崎县各地进行菌株选定、实验室比对测试等等..。采集菌株当时其中有一地点位于一养蜂场附近,前田教授观察到,在自然涌出的水源地周围不时有蜜蜂飞来盘旋。当时特别在自涌水池中取样，进行菌株分离、筛选。从数百菌株反复测试时发现其中Pseudomonas 属的新型菌株(MS-1)具有高机能性、证明可以有效抑制病毒。
接着连续数年持续进行大规模动植物露地试验并与养蜂协会所选定之杰出蜂场同步合作进行测试。 2008年新型益生菌株与相关证明资料检送日本专利微生物研究托管中心(NPMD)评鉴审核后列为安全益生菌株。 (依国际微生物鉴定法、MS-1株的16SrRNA遗传子排列情报分析、安全确认完成/日本政府制品评価技术基盘机构Bio Technology Center认定属安全菌株第一级）。MS-1新型益生菌株可安全被应用在蜜蜂昆虫、人体保健及动植物、水圈生物等广泛分野。
前田博士与研究室全员竭力开发之不懈热忱跟民间的全力配合奉献力量是MS-1新型机能益生菌株能被顺利开发的最大功臣。 MS-1益生菌种株也在2008年寄存于曰本国家专利菌株专门托管中心。 (IPOD,NITE/WIPO member ; http://www.nbrc.nite.go.jp)
2009年7月全世界唯一蜜蜂专用MS-1优势机能菌混合饲料(スーパービー)在蜂农引颈企盼下终于正式开始贩售。前田博士运用自然环保技法成功开发出商品、受惠对象非常广泛；蜜蜂、蜂农、果农、更保障日本国产的蜂蜜相关产品在国内外市场上安全、高品质地位与口碑。2012年1月MS-1新型机能性益生菌[蜜蜂益活菌]的日本专利成功通过审核。
优健88⁺[蜜蜂益活菌] 純粹天然健康食品也顺利通过核准正式在日本问世。
http://www.asahi.com/eco/SEB200906170047.html(朝日新闻社- 蜜蜂用益菌大发现报导）http://www.yukan-daily.co.jp/news.php?id=7406(夕刊Daily-拯救蜜蜂的微生物发现报导) An environmentally friendly bio technology
＊＊＊新規機能性善玉菌[ミツバチ善玉菌]誕生の経緯＊＊＊
（日本特許第4913117号）
1973年、ノーベル生理学賞と医学賞を受賞したカール・フォン・フリッシュ博士は、ミツバチの鋭敏な環境感知能力と高いコミュニケーション能力を証明しました。環境の変動や農薬などに敏感に反応し、個体数が減少してしまったように、ミツバチと自然環境とは切り離せない関係です。
近年、世界各地でミツバチの突然の大量死や失踪現象が進行していますが、科学者たちはこの憂慮すべき現象を引き起こす主な要因を、栄養不足、免疫力低下、電磁波、農薬の大量使用、抗生物質、化学肥料、虫害、ウイルス感染などとしています。
2005年、日本養蜂はちみつ協会 (http://bee.lin.gr.jp/) は、上記の要因の中でウイルス感染と免疫力低下などで起こるミツバチの大量減少や大量死の問題を解決するために、バイオコントロール（従来の薬剤に代えて優性機能菌株でウイルスなどの悪玉菌を抑える方法）の分野において顕著な研究成果と実績を持つ前田昌調博士(宮崎大学農学部教授）に研究を依頼しました。
前田教授(Dr. Masachika Maeda、専門：微生物学）は研究チームを率いて宮崎県内各地から菌株を選定し、実験室で検証テストを行いました。研究過程でミツバチがよく飛来する湧水池に気付き、その湧水から微生物群を分離、培養しました。数百菌株のテストの結果、その中で新種細菌株が優れた機能を持ち、ウイルスを抑えることも証明しました。
それから、数年間にわたって大規模な動植物投与試験、及び養蜂協会が選定した養蜂場での合同テストを行いました。そして、新型菌株と関連研究資料を特許微生物寄託センター（NPMD）に送り、鑑定を受け、安全が証明されました。（国際微生物鑑定法、16SrRNA遺伝子配列情報分析により安全確認／（独）製品評価技術基盤機構バイオテクノロジーセンター認定安全菌株レベル１）この新型善玉菌株はミツバチ等昆虫、人、動植物、及び水生生物等、広範な分野に応用することができます。2008年にバイオテクノロジーセンターに寄託保管しました。
(IPOD,NITE/WIPO member ; http://www.nbrc.nite.go.jp)
前田博士とその研究チームの研究開発に向けた技術と情熱及び民間企業の全面的協力のおかげで、ミツバチの研究から発見した新規機能性善玉菌株を順調に開発することができました。
2009年7月、世界で唯一の新規機能性善玉菌株からなるミツバ
そして2012年1月に新規機能性善玉菌[ミツバチ善玉菌]の日本特許を取得しました。
この新規機能性善玉菌を主成分とした健康食品優健ピュア⁺は認可を受けて、正式に日本で販売を始めます。
http://www.asahi.com/eco/SEB200906170047.html
(朝日新聞社記事―お疲れミツバチにどうぞ 群れを元気にする善玉菌発見）
http://www.yukan-daily.co.jp/news.php?id=7406(夕刊デイリ―ミツバチ救う微生物発見)
The development of Probio 88⁺
The story of MS-1
A new functional probiotic strain
(Japanese Patent No. 4913117)
In 1973, Dr. Karl von Frisch received the Nobel Prize in Physiology or Medicine. He proved that bees have high environmental sensibility and communication skills among themselves. The changes of our natural environment are closely related to organisms such as these bees with highly developed sensory perceptions.
The large number of sudden deaths and disappearances of honey bees around the world has been a serious problem in recent years. Scientists and honey bee experts have been trying to find the causes of this threatening problem. Theories put forward for this situation have included: low immunity, electromagnetic radiation, the overuse of pesticides, antibiotics, chemical fertilizers, pests and viral infection.
In 2005, The Japan Bee Association (http://bee.lin.gr.jp/) proposed a special project to Dr. Masachika Maeda, Professor at the Faculty of Agriculture at the University of Miyazaki, who is a well-known specialist in the field of biological sciences, and has an outstanding research record, especially in microbio-control sciences. Dr. Maeda has had a long research career in investigating the technology of the isolation and utilization of functional probiotic microorganisms which promote growth in living things, and which at the same time repress the growth of pathogenic microorganisms. This environmentally friendly scientific method can provide an alternative to overused antibiotic treatments. It would solve one of the problems causing the dramatic decrease in the number of honey bees by helping to strengthen the bees’ immune system and viral suppression.
Dr. Maeda led the research team in selecting the strains and doing the laboratory experiments. While collecting samples, he visited a place where a spring water pond was located near a honey farm. Dr. Maeda observed that above the natural spring water, honey bees sometimes flew around and drank it, so he decided to focus his sample collecting on the water and wet soil around the pond. The microorganisms in the samples were then isolated, cultivated and identified using taxonomic methods. Hundreds of strains of microorganisms were identified and then screened for functional probiotic effectiveness. After numerous experiments, a new strain, Genus Pseudomonas fons strain (MS-1), was found to have functional characteristics and was proven to be effective in inhibiting viruses. For the next few years, large scale field tests were carried out on plants and animals. Field tests were also carried out on bees in collaboration with the beekeepers assigned by the Japan Bee Association.
In 2008, MS-1 strain with all the relevant information, including experimental data and field tests results, were submitted to the Japan National Institute of Technology and Evaluation, Patented Microorganisms Depositary (NPMD). After further evaluation and classification, the new strain was classified as a safe probiotic strain. (The MS-1 strain was subjected to 16SrRNA analysis and identification was completed. The NPMD identified the strain as a safe, 1st level microorganism). The new probiotic microorganism strain, MS-1, can be widely applied to bees, insects, husbandry animals, fish as well as human beings and biological related industries. Without the research team members’ great efforts and the full support of other laboratories and the bee keepers, MS-1 would not have been developed and utilized successfully. In 2008, the MS-1 strain was deposited in the Japan Patented Microorganisms Center. (IPOD, NITE / WIPO member; http://www.nbrc.nite.go.jp)
In July 2009, after a long wait, a specially designed feed for bees (SuperBee), containing MS-1, started to be supplied in Japan. Many groups including beekeepers, farmers and honey lovers, have benefitted directly and indirectly from the introduction of this new feed. This new product has helped to strengthen the bees’ immune system so that bees have strong immunity to resist viral infection or diseases. It provides a natural method that also inflicts minimal or no harm on the environment: an environmentally friendly bio technology.
This nature-friendly method ensures safety and the highest quality in the production of honey and its related products. Moreover, Japanese made honey is strongly recognized as an eco-friendly product throughout the world.
In January 2012, the MS-1 probiotic microorganism strain (also called bee probiotics) successfully obtained a Japanese Patent.
Now MS-1 is also available as a health supplement called Probio 88⁺.
An environmentally friendly bio technology
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